Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap
نویسندگان
چکیده
Abstract The use of optical tweezers to measure forces acting upon microscopic particles has revolutionised fields from material science cell biology. However, despite control capabilities, this technology is highly constrained by the properties probe, and its may be limited due concerns about effect on biological processes. Here we present a novel, optically controlled trapping method based light-induced hydrodynamic flows. Specifically, leverage capabilities convert translationally invariant topological defect flow field into an attractor for colloids in effectively one-dimensional harmonic, yet freely rotatable system. Circumventing need stabilise particle dynamics along unstable axis, novel trap closely resembles isotropic tweezers. Using magnetic beads, explicitly show existence linear force-extension relationship that can used detect femtoNewton-range with sensitivity close thermal limit. Our force measurements remove laser-particle contact, while also lifting constraints, which renders them particularly interesting tool life sciences engineering.
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ژورنال
عنوان ژورنال: eLight
سال: 2021
ISSN: ['2662-8643']
DOI: https://doi.org/10.1186/s43593-021-00007-7